New prescription recommendations have been published for antimicrobial drugs against C. difficile infection

UK – The UK’s National Institute for Health and Care Excellence (NICE) and Public Health England (PHE) have published a new jointly developed guideline on antimicrobial prescribing for Clostridioides difficile (C. difficile) infection. Under the new recommendations outlined in the guidelines, advice for managing C. difficile infection in both community and hospital settings has also been included. The guideline has made a change to current practice, recommending that the first-line choice of antibiotic for adults for a first episode of mild or moderate C. Difficile infection should be oral vancomycin…

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National Institute for health and Care Excellence to issue guidelines for rare blood clot associated with COVID-19 vaccines

UK – The National Institute for Health and Care Excellence (NICE) is planning to develop a plan for the management and treatment of rare blood clots and hematological related conditions associated with COVID19 vaccines. Aims of the guidelines are to combine the best knowledge that will help support clinicians in their diagnosis and treatment of individuals with such related conditions. NICE is at the moment in collaborative talks with experts from the Hematology related organizations as it will try and review the evidence for identifying and managing blood related conditions.…

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National Institute for Health and Care Excellence rejects Orchard Therapeutics’ gene therapy libmeldy

UK – The National Institute for Health and Care Excellence (NICE), has discouraged the use of Orchard Therapeutics’ gene therapy Libmeldy. NICE highlighted that although the clinical trial evidence suggests the drug improves motor and cognitive function and could correct the enzyme deficiency caused by MLD, its long-term stabilization of symptoms was very uncertain. Ortho Therapeutics, a global gene therapy leader, developed Libmeldy for the treatment of metachromatic leukodystrophy (MLD) in children. MLD is a rare hereditary disease characterized by accumulation of fats called sulfatides and causes the destruction of…

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