This study also found that the inhaled version of the vaccine did not cause serious side effects, demonstrating an encouraging safety profile in the early-stage trial.
Globally, amid the COVID-19 crisis, the market for Respiratory Inhalers estimated at US$33.9 Billion in the year 2020, is projected to reach a revised size of US$51 Billion by 2027, growing at a CAGR of 6% over the period 2020-2027.
Still in China, a team of researchers has developed an inhalable dry powder formulation of tamibarotene, a repurposed drug, which has shown broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV and influenza A H1N1 virus following pulmonary delivery in animal models.
The team, led by the University of Hong Kong (HKUMed), prepared the inhaled dry powder formulation of tamibarotene by spray freeze drying, a particle engineering technique that combines spray freezing and freeze-drying to produce particles with excellent aerosol properties for inhalation.
This research found that a dose of tamibarotene powder delivered by intratracheal administration significantly reduced virus titer and viral RNA load of SARS-CoV-2 in the hamsters’ lungs, and the antiviral efficacy was comparable to intratracheally administered remdesivir.
The broad-spectrum anti-coronavirus activity of inhaled tamibarotene powder was also demonstrated in the MERS-CoV-infected mice model as pre-challenge prophylaxis.
Moreover, remarkable anti-influenza activity of tamibarotene powder formulation was demonstrated by the improved survival rate of mice and alleviated disease severity when administered either intratracheally as prophylaxis or intranasally as treatment.
AR-712 is being developed as a self-administered, at-home inhaled treatment for COVID-19 patients who are not yet hospitalized.
The product candidate is designed to substantially lower the barrier to treatment of COVID-19 patients and encourage treatment much earlier in the course of their disease within the patients’ own homes.
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